منابع مشابه
HIV-1 Escape From RNAi Antivirals: Yet Another Houdini Action?
To the Editor: Since the identification of HIV-1 as the primary cause of AIDS, much effort has been made to develop therapies that potently inhibit virus replication. Unfortunately, HIV-1 uses an error-prone replication machinery that allows the virus to rapidly adapt to new conditions. As a consequence , early single-drug therapies failed because of the rapid appearance of drug-resistant virus...
متن کاملAntivirals in the context of HIV disease.
Antiviral drugs, other than those with anti-retroviral activity, are used in persons with human immunodeficiency virus (HIV) infection for two purposes: treatment or prevention of viral infections that cause disease in persons with immunodeficiency, and to suppress viruses that might act as co-factors and promote replication of HIV itself. Human herpesviruses are the major targets of therapy in...
متن کاملResponse to “HIV Escape From RNAi Antivirals: Yet Another Houdini Action?”
To the Editor: In his 1909 book Handcuff Secrets, Harry Houdini lifted the shroud of secrecy surrounding his performances and revealed that his mystifying capacity to escape shackles and chains was based in painstaking effort and compromise. Shaking off straightjackets for example required dislocating his shoulders, performance after performance, year after year. In the current issue of Molecul...
متن کاملGenetically engineered crops and pesticide use in U.S. maize and soybeans
The widespread adoption of genetically engineered (GE) crops has clearly led to changes in pesticide use, but the nature and extent of these impacts remain open questions. We study this issue with a unique, large, and representative sample of plot-level choices made by U.S. maize and soybean farmers from 1998 to 2011. On average, adopters of GE glyphosate-tolerant (GT) soybeans used 28% (0.30 k...
متن کاملValuing Product Innovation: Genetically Engineered Varieties in U.S. Corn and Soybeans
We develop and estimate a discrete-choice model of differentiated products for the corn and soybean seed industry in the United States to assess the welfare impact of genetically engineered (GE) crop varieties. We use a unique dataset, spanning the period 1996-2011, that contains rich information on the adoption of GE traits. Using a two-level nested logit model, we estimate that U.S. farmers a...
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ژورنال
عنوان ژورنال: Science
سال: 2015
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.347.6223.733-a